It uses a basic keyDoes your van use a PATS key or a regular one? If it uses a PATS key you'll have to program the ECU for it.
It uses a basic key
Im not sure offhand when Econolines started having a VIN stored in the engine control module offhand but there will be a vin mismatch if it stores a vin. Per the ford calibration website there are 51 different possible engine calibrations for a 2004 econoline with a 5.4 (just picked an engine). Hardware is the same for all 51 calibrations. So yeah, its most likely going to need programming by someone that knows how to do blank path programming to change the calibration & vin