6) Silicone fluid is functionally incompatible with systems that have held glycol-based fluids for any length of time, requiring flushing and seal replacement (there are counter opinions on this, which state that the modern silicone formulations are in fact compatible with only a flushing, rather than a complete reseal). The actual DOT specification requires chemical compatibility, so as far as that goes, the two fluids won't cause reactions if used in the same system, but they certainly won't mix, either.