at the same time, consider OTR trucks. Lots of overdrive, low RPMs, steady-state driving. Those trucks go a million miles or more, very often.
Id suggest that longevity is mainly a function of power output. a 3000 lb. car, going 60 mph needs ~60hp or so. That same 3000 lb car accelerating to 60 MPH, particularly if not driven gently, is using much more than 60 hp. That car, whether its geared high or low, going along at 3500 rpm or 1500 RPM, still needs more or less the same amount of power, even if the mechanical advantage from the gearing is wildly different. In a word, both power requirements are low.
Ill bet it takes more power to contantly accelerate away from stoplights to 30 mph, than it does to cruise at 60 mph. that power output puts thermal (remember, an IC engine is only about 30% efficient, so for every 100 hp, there iw 200 hp worth of waste heat emitted and transferred through the moving parts) and mechanical stresses on the parts, not to mention the oil.
an econobox that does 3500 rpm at 65 mph and has 200k miles likely has seen less overall stress than a more powerful, slower revving car that does stop and go all the time, especially if they have a heavy foot...
JMH