His original setup many years ago (at this point decade +) was an automatic, some body/aero mods and changeable rear axle ratios so he could tow or highway cruise. From memory That airplane rear netted him 40mpg+ without any fancy driving.
If you have an overhead hoist, quick connects and pulse tools maybe it would be worth swapping the rear axle between hauling season and cruising season (from what I remember he towed a lot certain months of the year so the axle stayed put much of the time)
My 2wd 82 diesel suburban had a 2.8 rear and a 5 speed granny/ overdrive. Had to really slip the clutch with an 18ft enclosed trailer but most of the time I had the rear seats down, a trailer hitch support slung on the rear for the tent and flirted with 30mpg at 55mph. I had 15” tires, and the truck sat quite low compared to the ops setup.
The ops non-locking turbo 400 with big wheels likely has a MPG sweet spot with a very different rear end depending on his typical speed. Guessing 3.02-3.5ish depending on how much she slips.