I have a Honda Civic wagon with 376k miles and the only major repair was the replacement of the camshaft about 100k miles ago. I put myself thru college buying smokers, cleaning them up and selling them. Here is what I'd do. Take the car to your local Honda repair shop (a clean one) and have the car checked, just like buying a used car. If you think it's worth keeping, have any safety related workd done. Then start on the engine. Pour a pint of Marvel Mystry Oil in the crankcase and drive it for a couple of hundred miles. Check the oil filter to see if it feels warm when the engine warms up, if not it's plugged, change the oil and filter. Do this cycle of changing the oil, adding a pint of MMO, drive a couple of hundred miles and change it again, three times. Use a good 10w-30 dyno oil and be prepaired to add oil during each cycle. During these three cycles add MMO to the gas tank following the instructions on the bottle, no more, no less. When done get a new filter and one of those big jugs of Mobil 1 15w-40 (Wal-Mart) oil and you're on your way. Just keep a hand on that oil filter to see if it's not quite as warm as it should be.
With my Honda I add a pint of MMO about once a year or when it starts to smoke on startup or when letting off the gas comming up to a stop sign. I use a synthetic oil and have, thru 20 years, gone from 5w-30 to 10w-30 to 10w-40 and now 20w-50 base on oil consumption. I have original compression and the car runs great. With careful driving I'm getting 37/40 mpg and the engine head has not been off. I change the oil at 5k intervals and it burns about half a quart in that time. When it starts to smoke on start up I do not notice an increase in oil consumption. By the way I think synthetic is worth considering if you keep cars more than two or three years. Synthetic is better in every way except the purchase price.
Then it's time to get after the coolant, brake fulid and transmission, all thing you can do in the driveway.