John Deere doesn't call Plus 50 II "synthetic". John Deere markets toward their own lubricants, so I'm guessing it's one way to keep you from buying a competitor's lubricants.
What year machine? I run a 2022 318G and a 2024 325. I'll double check as i know they allow some engine oils and other hydraulic fluids but they spec their Hydrau XR as factory fill, which is a synthetic fluid.