If you want a sensible hybrid (assuming that's not an oxymoron, as many believe) with some cargo volume, the Highlander is hyb is the way to go. It is pricy, but if you're willing to settle for a more basic version with cloth seats, those are appearing with MSRPs in the low-30s. The Limited versions are way up there around 40-ish. The SUV hybrids are, to me, strange animals. As noted above, the Lexus is just silly. How do you justify spending 50-60k on a vehicle (as with its close relative the Highlander, almost a 10k premium over the straight gas version) to save a little on gas??? Even baseline Highlander Hybrids are going to be pretty hard to justify on a purely mathematical basis.
They are also strange because of their lopsided mileage profiles. The Highlander Hyb is rated 33 city and 28 highway. Nowhere near the dramatic overall stinginess of the Prius, and the highway figure is barely better than a normal V-6. So the benefits are heavily in favor of the city driver, almost totally pointless for the guy who drives long distances.
But as always, it comes down to preferences. If you want a hyb SUV with some room, go check out a Highlander. If you're comfortable and can pay the freight, go for it. Just don't expect to get your money back in gas savings, unless you own the thing for a very, very long time.