I go by preference. Have a couple bikes and when I ride, it's rare that the ride is an hour or less. Most are a couple hours to a full day. Longest ride was 16-1/2 hours run time in a day 2-up (wife on the back). So since I don't have much short term riding, I went with synthetic. I use Rotella 5w-40 in one bike and Amsoil 20w-50 in the other bike. I switched to synthetic a few years ago.
If I rode mostly local short runs, then I probably would have stayed with the dino I used to use.
One thing I do notice is both of these bikes run cooler and the upper is more quiet. These bikes I have seem to like it.
Unexpected was the Amsoil 20w-50 switch in the older Harley. I was used to adding a little oil 1-2 times a month to maintain a 3/4 level in the oil tank, not much but I like to maintain a level. Since I switched it to Amsoil, I only add a very small amount about twice a year. Oil consumption dramatically went down. I only have 25k on the bike.
On the down side, It really takes some riding to get the temp up on it, and I can hardly get the temp to 180. Now the other day when it was about 40 out, I don't think the oil temp got over 150, or it may have been 160. I didn't have my glasses on at the time. Also, I'm on my 3rd oil temp gauge, and each has reacted the same. I don't like the temp that cold, but the oil is the best I have ran in it during summer.
In the summer when it's near triple digits, I still have to run it a bit and harder to reach 180. Most of my riding is 2-up. On the hot days and some harder riding, I have at times reached 200F (12 o-clock on the gauge), but not often. It just doesn't seem right - but I can sit idle at long red lights and not worry about it for an air cooled bike (Harley).
Runs cooler, quieter, reduced oil consumption, oil last longer - I guess the positives outweigh the negatives.
On some of my other previous bikes, some were touchy depending on which oils I used. Wet clutch bikes usually need a non energy conservative oils as the clutch could start slipping. The bikes with one hole - oil shared; engine, transmission, clutch, I think is asking allot from an oil. So I like the shear factor associated with the synthetics. I've had the clutch friction zone smooth out.
So I been full synthetic all around a few years and I like it.
Another note - I have not seen any confirmation yet, but some Buell boys think there is a higher failure stator rate which may have some association with the use of M1. Something about the add pack, crankcase condensation, not getting it burned off, results in the add pack formulation/ppm's creating a light acid not favorable with the stator coat. I have never had a stator failure and I have never used M1 in any of my bikes ever, with the exception of using M1 synthetic gear oil in a shaft driven final drive unit.
Now lets talk spark plugs - Iridium plugs - okay done.......