That's what I done on my Honda Accord, it took 4 or 5 drain/fills, I done a few more just to make sure. By the way make sure you run the heat wide open to get that flushed out as well. Find the capacity of your cooling system, after you have drained/filled with distilled water, and get only clear water on the drain, then add enough coolant (make sure you get the unmixed coolant) to put your system at the desired mix , so if it' 2 gallons, and you want 50/50 on your last drain of distilled water add coolant, if you do not get a full gallon in after you burp all the air out, just drain some more until you get the full gallon in, you will loose some percentage, however it will be so little as to be not even worth the worry. I had to do this with a pre-mix coolant, so I had a little more fun.
The simple answer, just get your cooling system capacity, calculate what it will take to get the desired mixture 50% or 75%, then after you have flushed it to get a clean/clear drain (remember the heater wide open each time) add the amount of coolant to make the mixture correct, even if you have to drain some of the already mixed coolant out, it will be real close.
On edit, just so you know, I have done this several times, and most of the time you will get about half of the coolant out on a drain, so you can get a 50/50 mix on the first fill, if you want the 75% just drain until you get the correct amount in, very simple, I just get to entwined in typing out directions LOL
Clint