I put a set on my 2001 2wd shortbox Silverado, based on price, tirerack, and recommendations here. Best thing is the price. Wet and dry traction are excellent. Haven't tried them on snow or ice yet.
These tires replaced the original General 255-70R16's, and I do have a couple complaints. The Destinations have about 1.5" less tread width. And while traction is better, I don't like the ride as much--the Generals felt firmer. "Squishy" and "bouncy" are the best terms I can think of, and they feel sloppy on the highway compared to the original tires.