Why not just install a quality air filtration system on your furnace? That way the entire house is filtered all the time, in both winter heating and summer cooling, and you don't need to worry about filters or several small units.
Simple idea that falls short on being able to filter out all the "culprit" particles for certain people. This depends on the needs of the individual of course. I say this because we initially did that exact setup and it did help. Adding the additional purifiers are what put my daughter under the threshold of immediate physical difference. This is really based on individual needs and some people can get away with doing just a quality air filtration on a furnace setup. Other people need more than that. We did.
This is also dependent on what the space you are filtering is like. In our case the entire house is hardwood and tile floors except the bedrooms. They all have carpet. The carpet is our biggest source of trapping allergies for our daughter. The furnace filter does a decent enough job for the main part of the house, for us anyway, but doesn't do enough for the bedrooms while sleeping and playing (for my daughter that is) to make the difference. We just had to supplement in these areas.