The magazines always talk about crankshaft gyroscopic effect, and how larger engines are more reluctant to turn. Not that the larger engined bikes are slower in corners, just that they take more effort to enter the corner.
While I'm no expert, I'm not sure I agree. I simply can't ride a small bike as effectively as I can a larger one. Maybe it's because of my 210 pound weight, or maybe it's just what I grew up riding.
Certainly, there are many smaller engines with large flywheels and heavy crankshafts and many large engines with very light weight crankshafts.
My old RZ350 was a great example. It had a very heavy, complex crankshaft and flywheel assy. Yet, it dropped into corners with ease. My GPZ750 had a crankshaft that was actually lighter, but was far more reluctant to turn. I think overall weight, tire size and geometry play a bigger role.
I ride big bore dirt bikes. I simply cannot ride a 125 like I can a 500. The weight difference is not that much, yet the big bikes are easier.