I have a '12 Camry LE with the 2.5 that's coming up on 80k (I bought it 3 years ago with 30k) that's been very solid; I'd buy another one in a heartbeat. My Camry easily pulls down 35mpg on the highway, and has plenty of power - no reason to go with the V6, although that does produce fantastic power. Its only repair so far has been rear brake pads/lube after a stuck slide pin sort of jammed the rear caliper (due to road salt), but I did replace the 8-year-old factory battery for peace of mind. It's a comfortable highway car that has lots of space, tons of storage, decent seats, and is pretty feature-dense (even my LE came with a touchscreen radio, stitched dash, power drivers seat, USB/aux/Bluetooth, etc. in addition to all the keyless/power features that you'd expect, so it feels decently upscale and modern). I added a backup cam (standard on later years) and an auto-dimming mirror with compass; both were pretty easy projects.
We have a mechanically-similar '10 Sienna with the 3.5 that's at about 220k, and has been amazing to own - pretty much just tires/brakes/batteries, plus a VVT repair that cost ~$400-$500, as I remember. It still has its original ATF, brake fluid, coolant, and all original suspension parts. Basically just brakes and tires and air filters, one or two light bulbs, a refrigerant top-off a few years back and a radio under warranty for a jammed cd, plus oil changes every ~7500. It still feels almost as good at 200k as it did at 100k. It's been incredibly cheap to own and still pulls 24+ mpg down on the highway, same as new.