Everything depends on the mission the airplane is designed for. How many seats, payload, range, training costs, financing available are all factors that determine the operating costs of the aircraft.
At my former Northwest Airlines, the A320's were purchased for an extremely low price initially, but more expensive for purchasing spare parts and replacement items. The airplane was also called the "Bic" airplane because it was considered disposable after 25 years due to the aircraft construction (difficult to replace carbon fiber wingboxes, etc. Cheaper to buy a new airplane.)
I flew the A320 for only 6 months so I didn't really get too comfortable with the Airbus philosophy. The A320 was designed by engineers, for engineers. It has a very layered flight controlled computer system, which can cause serious problems if you do not understand what the airplane is doing and why. See the Air France Rio to Paris accident report to see what confusion can do.
IMHO, the Airbus cockpit is also "cheaper" in that many materials used were plastic and didn't have that same ergonomic feel that you get in a Boeing Aircraft, i.e., switches, instruments, radar display, map lights, etc.
You can tell I am a fan of Boeing. I have flown Boeing products for over 20 years and like how they are built very well, the systems are logical, and the airplanes last a very long time.
More importantly, I trust a Boeing. Not too complicated, easy to learn the systems, easy to fly.
Just my .02 from a pilots point of view.
757guy