Lol, I just realized you had a quote from me in your signature......
As for the OP, likely fine. I'm not aware of any cooling related problems (I'm specifically thinking of RAM and their plugged heater cores) that F150's have.
I changed out the Ranger at 60k/5 years, just because it is fairly easy, the Zerex Yellow is cheap enough (this stuff:
https://shop.valvolineglobal.com/pr...-yellow-50-50-prediluted-antifreeze?Size=1+GA), it is hot down here in the south, I worked that truck hard, and you only swap out some of the coolant anyways, so I figured a D&F every 60k or so would do the trick.
I will likely follow a similar schedule with the new F150, although I have no idea what I'm going to do with the 'low temp cooling circuit' for the Hybrid stuff.