IMHO, the V6 is under powered for a full size truck. The manual transmission will help a bit with power, but it still lacks power.
They feel good on a test drive, but I don't know anybody who ever bought one that didn't regret not going for the small V8.
If you baby it, the fuel economy may be better, but if you try to get that extra little bit of power, the engine has to work hard, sucking more gas than a small V8.