We had a 2004 Odyssey with 182,000 miles. No problems other than motor mounts. Trans fluid was changed every 10k with Maxlife.
Our 2010 has 66k. Again, no problems. I've disabled the VCM with a MuzzlerII and use Mobil 1 Ow-40, and Maxlife in the trans.
I do have a great independent Honda tech...